Evandro M. Neto Neves, Indiana University
Dr. Neves is a Postdoctoral fellow in
Emergency Medicine at Indiana University in the lab of Dr. Jeff Kline, Professor of Emergency Medicine and Physiology. His current research interests
focus on the study of cardiovascular diseases, including pulmonary
embolism (PE) and right ventricular dysfunction. His main hypothesis is
that activated proteases, such as matrix metalloproteinases (MMPs) may
contribute for the right ventricular and lung vasculature damaged
following PE. Interestingly, he and his colleagues have found that doxycycline
(an MMP inhibitor) attenuates PE-induced pulmonary hypertension and also
protects the heart against damage (prevents troponin I release and right
ventricular dilation). In addition, he believes that MMP inhibition could be a
useful strategy to decrease mortality and morbidity after PE in the future. Dr.
Neves is a recipient of a 2015 MCS Pappenheimer Travel Award.